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KMID : 0869220220260020076
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Journal of Korean Geriatric Psychiatry
2022 Volume.26 No. 2 p.76 ~ p.83
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Higher Fat-Related Body Composition Measurement and Lower Resting-State Inter-Network Functional Connectivity of APOE ε4 Carrier in Mild Cognitive Impairment Patients With Aβ Deposition
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Choi In-Hyeok
Wang Sheng-Min
Um Yoo-Hyun
Lim Hyun-Kook
Lee Chang-Uk
Kang Dong-Woo
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Abstract
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Objective: We aimed to evaluate the impact of interaction between APOE ε4 carrier status and body composition measurements on intra- and inter-regional functional connectivity (FC) in mild cognitive impairment (MCI) patients with Aβ deposition.
Methods: MCI patients with and without APOE ε4 allele (carrier, n=86; non-carrier, n=95) underwent neuropsychological battery, resting-state functional magnetic resonance imaging scans, positron emission tomography scans with [18F] flutemetamol, and bioelectrical impedance analysis for measuring body composition. We employed a priori defined regions of interest to investigate the intra- and inter-network FC profiles of default mode network (DMN), central executive network (CEN), and salience network (SN).
Results: There was a significant interaction of APOE ε4 carrier status with body fat mass index, visceral fat area, and waist-hip circumference ratio for inter-network FC between DMN and CEN, contributing higher fat-related body composition measurements in the APOE ε4 carrier with lower DMN-CEN FC.
Conclusion: The present results highlight the detrimental effect of APOE ε4 carrier status on the associations between the fat-related body composition measurements and FC in the MCI patients with Aβ accumulation.
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KEYWORD
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Body composition, APOE ε4-carrier, Bioelectrical impedance analysis, Functional connectivity, Mild cognitive impairment
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